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Nat Cell Biol. 2013 Jul;15(7):727-8. doi: 10.1038/ncb2797.

ULK1 targets Beclin-1 in autophagy.

Abstract

The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.

PMID:
23817237
PMCID:
PMC4442023
DOI:
10.1038/ncb2797
[Indexed for MEDLINE]
Free PMC Article
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