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J Biol Chem. 2013 Aug 16;288(33):23622-32. doi: 10.1074/jbc.X113.497321. Epub 2013 Jun 26.

Chaperonin-mediated protein folding.

Author information

1
Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut 06510, USA. arthur.horwich@yale.edu

Abstract

We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments.

KEYWORDS:

Chaperone Chaperonin; Molecular Chaperone; Polypeptide; Protein Folding; Protein Misfolding; Yeast

PMID:
23803606
PMCID:
PMC3745308
DOI:
10.1074/jbc.X113.497321
[Indexed for MEDLINE]
Free PMC Article

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