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Cancer Cell. 2013 Jun 10;23(6):725-38. doi: 10.1016/j.ccr.2013.04.009. Epub 2013 May 23.

Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Molecular programs that mediate normal cell differentiation are required for oncogenesis and tumor cell survival in certain cancers. How cell-lineage-restricted genes specifically influence metastasis is poorly defined. In lung cancers, we uncovered a transcriptional program that is preferentially associated with distal airway epithelial differentiation and lung adenocarcinoma (ADC) progression. This program is regulated in part by the lineage transcription factors GATA6 and HOPX. These factors can cooperatively limit the metastatic competence of ADC cells, by modulating overlapping alveolar differentiation and invasogenic target genes. Thus, GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype.

PMID:
23707782
PMCID:
PMC3697763
DOI:
10.1016/j.ccr.2013.04.009
[Indexed for MEDLINE]
Free PMC Article

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