Format

Send to

Choose Destination
J Am Chem Soc. 2013 May 15;135(19):7122-5. doi: 10.1021/ja402761p. Epub 2013 May 3.

Rhodium(III)-catalyzed indazole synthesis by C-H bond functionalization and cyclative capture.

Author information

1
Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Abstract

An efficient, one-step, and highly functional group-compatible synthesis of substituted N-aryl-2H-indazoles is reported via the rhodium(III)-catalyzed C-H bond addition of azobenzenes to aldehydes. The regioselective coupling of unsymmetrical azobenzenes was further demonstrated and led to the development of a new removable aryl group that allows for the preparation of indazoles without N-substitution. The 2-aryl-2H-indazole products also represent a new class of readily prepared fluorophores for which initial spectroscopic characterization has been performed.

PMID:
23642256
PMCID:
PMC3656829
DOI:
10.1021/ja402761p
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center