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Nat Genet. 2013 May;45(5):473-5. doi: 10.1038/ng.2617.

Cancer chromosomes going to POT1.

Author information

1
Department of Laboratory Medicine and Pathology at Yale University School of Medicine, New Haven, Connecticut, USA. s.chang@yale.edu

Abstract

Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.

PMID:
23619786
PMCID:
PMC4040961
DOI:
10.1038/ng.2617
[Indexed for MEDLINE]
Free PMC Article

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