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Dev Cell. 2013 Apr 15;25(1):1-2. doi: 10.1016/j.devcel.2013.03.020.

Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.

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Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06509, USA.


Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct4, Nanog, and Sox2.

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