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Nat Rev Microbiol. 2013 May;11(5):316-26. doi: 10.1038/nrmicro3009.

Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors.

Author information

1
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA.

Abstract

Several bacterial species have evolved specialized secretion systems to deliver bacterial effector proteins into eukaryotic cells. These effectors have the capacity to modulate host cell pathways in order to promote bacterial survival and replication. The spatial and temporal context in which the effectors exert their biochemical activities is crucial for their function. To fully understand effector function in the context of infection, we need to understand the mechanisms that lead to the precise subcellular localization of effectors following their delivery into host cells. Recent studies have shown that bacterial effectors exploit host cell machinery to accurately target their biochemical activities within the host cell.

PMID:
23588250
PMCID:
PMC3859125
DOI:
10.1038/nrmicro3009
[Indexed for MEDLINE]
Free PMC Article

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