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Chem Commun (Camb). 2013 May 25;49(42):4749-51. doi: 10.1039/c3cc41452c.

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

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1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

PMID:
23579860
PMCID:
PMC3968531
DOI:
10.1039/c3cc41452c
[Indexed for MEDLINE]
Free PMC Article
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