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Cell Metab. 2013 Mar 5;17(3):311-2. doi: 10.1016/j.cmet.2013.02.014.

Novel SIRT1 mutation linked to autoimmune diabetes in humans.

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Departments of Immunobiology and Internal Medicine, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.

Abstract

Sirtuins are best known for their role in aging but also regulate many different biological processes. A study in this issue of Cell Metabolism (Biason-Lauber et al., 2013) now identifies a mutation in human SIRT1 causing a familial form of autoimmune diabetes.

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