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Neuron. 2013 Feb 20;77(4):599-601. doi: 10.1016/j.neuron.2013.02.002.

Is instability good for the brain?

Author information

1
Broad Center, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

In this issue of Neuron, Nahm et al. (2013) examine the Drosophila ortholog of spartin, the human gene mutated in a form of hereditary spastic paraplegia. Spartin inhibits BMP signaling and upregulation of BMP signaling may increase microtubule stability and neurodegeneration.

PMID:
23439113
DOI:
10.1016/j.neuron.2013.02.002
[Indexed for MEDLINE]
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