Format

Send to

Choose Destination
Physiol Rev. 2013 Jan;93(1):189-268. doi: 10.1152/physrev.00015.2012.

Gastric acid, calcium absorption, and their impact on bone health.

Author information

1
Department of Surgery and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.

Abstract

Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems.

PMID:
23303909
DOI:
10.1152/physrev.00015.2012
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center