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J Virol. 2013 Mar;87(6):3605-8. doi: 10.1128/JVI.03155-12. Epub 2013 Jan 9.

Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses.

Author information

1
Department of Immunobiology, Yale University, New Haven, CT, USA.

Abstract

Toll-like receptor 9 (TLR9) recognizes genomes of double-stranded DNA (dsDNA) viruses in the endosome to stimulate plasmacytoid dendritic cells (pDCs). However, how and if viruses with single-stranded DNA (ssDNA) genomes are detected by pDCs remain unclear. Here we have shown that despite the ability of purified genomic DNA to stimulate TLR9 and despite the ability to enter TLR9 endosomes, ssDNA viruses of the Parvoviridae family failed to elicit an interferon (IFN) response in pDCs.

PMID:
23302877
PMCID:
PMC3592163
DOI:
10.1128/JVI.03155-12
[Indexed for MEDLINE]
Free PMC Article

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