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Br J Psychiatry. 2013 Jan;202(1):14-21. doi: 10.1192/bjp.bp.111.107664.

Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis.

Author information

1
Division of Health and Social Care Research, King’s College London, London, UK. luis.ayerbe_garcia-mozon@kcl.ac.uk

Abstract

BACKGROUND:

Depression after stroke is a distressing problem that may be associated with other negative health outcomes.

AIMS:

To estimate the natural history, predictors and outcomes of depression after stroke.

METHOD:

Studies published up to 31 August 2011 were searched and reviewed according to accepted criteria.

RESULTS:

Out of 13 558 references initially found, 50 studies were included. Prevalence of depression was 29% (95% CI 25-32), and remains stable up to 10 years after stroke, with a cumulative incidence of 39-52% within 5 years of stroke. The rate of recovery from depression among patients depressed a few months after stroke ranged from 15 to 57% 1 year after stroke. Major predictors of depression are disability, depression pre-stroke, cognitive impairment, stroke severity and anxiety. Lower quality of life, mortality and disability are independent outcomes of depression after stroke.

CONCLUSION:

Interventions for depression and its potential outcomes are required.

PMID:
23284148
DOI:
10.1192/bjp.bp.111.107664
[Indexed for MEDLINE]

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