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Breast Cancer Res. 2012 Nov 15;14(6):114. doi: 10.1186/bcr3338.

Migratory gene expression signature predicts poor patient outcome: are cancer stem cells to blame?

Abstract

Breast cancer metastasis accounts for the majority of deaths from this disease. In the previous issue of Breast Cancer Research, Patsialou and colleagues used a novel in vivo invasion assay to capture migrating breast cancer cells and demonstrate that the gene expression signature of these cells predicts breast cancer metastasis in a large cohort of patients. Furthermore, specific genes identified play a functional role in the invasion of MDA-MB-231 breast cancer cells and in patient-derived breast tumors. These genes regulate pathways known to be induced in invasion and metastases and play an important role in the regulation of cancer stem cells.

PMID:
23153392
PMCID:
PMC4053126
DOI:
10.1186/bcr3338
[PubMed - indexed for MEDLINE]
Free PMC Article
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