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Cell. 2012 Nov 9;151(4):699-701. doi: 10.1016/j.cell.2012.10.026.

Capturing the cloud: UAP56 in nuage assembly and function.

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Yale Stem Cell Center and Departments of Cell Biology and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.


The nuage is a hazy electron-dense structure unique to germ cells and is enriched in components of the piRNA pathway. Although the nuage is cytoplasmic, Zhang et al. now show that it is organized by an intranuclear protein, UAP56.

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