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Neuroimaging Clin N Am. 2012 Nov;22(4):609-32. doi: 10.1016/j.nic.2012.04.004. Epub 2012 Aug 17.

Fungal infections of the central nervous system.

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Department of Radiology, Yale University Medical Center, New Haven, CT 06510, USA.


Fungal infections of the central nervous system (CNS) frequently occur in the immunocompromised or debilitated host. Imaging findings are non-specific but may be organized into extra-axial, parenchymal, and vascular categories. Furthermore, knowledge of fungal morphology may predict the imaging manifestations with large, hyphal species having a predilection for brain parenchymal involvement, while small, unicellular organisms typically result in meningitis. Advanced imaging techniques such as diffusion-weighted imaging, MR perfusion and MR spectroscopy, when combined with clinical findings, may help in differentiating fungal disease from other mimckers such as pyogenic infection or cystic metastases.

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