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Curr Biol. 2012 Oct 9;22(19):R849-51. doi: 10.1016/j.cub.2012.08.002.

Cancer biology: a new RING to Wnt signaling.

Author information

1
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. fearon@med.umich.edu

Abstract

The β-catenin-dependent Wnt signaling pathway has key roles in embryonic development and adult tissues and is defective in various cancers. Recent studies highlight the function of two transmembrane RING finger ubiquitin ligases in modulating Wnt signaling and reveal roles for mutations in the RING finger proteins in cancer.

PMID:
23058807
PMCID:
PMC4472467
DOI:
10.1016/j.cub.2012.08.002
[Indexed for MEDLINE]
Free PMC Article
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