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Nat Cell Biol. 2012 Oct;14(10):985-7. doi: 10.1038/ncb2596.

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Abstract

Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.

PMID:
23033049
PMCID:
PMC4047563
DOI:
10.1038/ncb2596
[Indexed for MEDLINE]
Free PMC Article

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