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Blood. 2012 Nov 15;120(20):4182-90. doi: 10.1182/blood-2012-05-427534. Epub 2012 Sep 28.

Self-antigen recognition by follicular lymphoma B-cell receptors.

Author information

1
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Follicular lymphoma is a monoclonal B-cell malignancy with each patient's tumor expressing a unique cell surface immunoglobulin (Ig), or B-cell receptor (BCR), that can potentially recognize antigens and/or transduce signals into the tumor cell. Here we evaluated the reactivity of tumor derived Igs for human tissue antigens. Self-reactivity was observed in 26% of tumor Igs (25 of 98). For one follicular lymphoma patient, the recognized self-antigen was identified as myoferlin. This patient's tumor cells bound recombinant myoferlin in proportion to their level of BCR expression, and the binding to myoferlin was preserved despite ongoing somatic hypermutation of Ig variable regions. Furthermore, BCR-mediated signaling was induced after culture of tumor cells with myoferlin. These results suggest that antigen stimulation may provide survival signals to tumor cells and that there is a selective pressure to preserve antigen recognition as the tumor evolves.

PMID:
23024238
PMCID:
PMC3501716
DOI:
10.1182/blood-2012-05-427534
[Indexed for MEDLINE]
Free PMC Article

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