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Immunity. 2012 Sep 21;37(3):389-98. doi: 10.1016/j.immuni.2012.08.011.

Innate immune recognition of HIV-1.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. akiko.iwasaki@yale.edu

Abstract

In contrast to the extraordinary body of knowledge gained over the past three decades on the virology, pathogenesis, and immunology of HIV-1 infection, innate sensors that detect HIV-1 had remained elusive until recently. By virtue of integration, retroviridae makes up a substantial portion of our genome. Thus, immune strategies that deal with endogenous retroviruses are, by necessity, those of self-preservation and not of virus elimination. Some of the principles of such strategies may also apply for defense against exogenous retroviruses including HIV-1. Here, I highlight several sensors that have recently been revealed to be capable of recognizing distinct features of HIV-1 infection, while taking into account the host-retrovirus relationship that converges on avoiding pathogenic inflammatory consequences.

PMID:
22999945
PMCID:
PMC3578946
DOI:
10.1016/j.immuni.2012.08.011
[Indexed for MEDLINE]
Free PMC Article

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