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Curr Biol. 2012 Sep 11;22(17):R692-4. doi: 10.1016/j.cub.2012.07.049.

Cell adhesion: a FERM grasp of the tail sorts out integrins.

Author information

1
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.

Abstract

As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.

PMID:
22974999
PMCID:
PMC5507346
DOI:
10.1016/j.cub.2012.07.049
[Indexed for MEDLINE]
Free PMC Article

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