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Annu Rev Genet. 2012;46:499-513. doi: 10.1146/annurev-genet-110711-155550. Epub 2012 Sep 4.

Neural regeneration in Caenorhabditis elegans.

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Department of Genetics, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, Connecticut 06510, USA.


Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

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