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Oncoimmunology. 2012 Aug 1;1(5):768-769.

Targeting the tumor mutanome for personalized vaccination therapy.

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1
TRON-Translational Oncology at the University Medical Center Mainz; Mainz, Germany.

Abstract

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.

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