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Physiology (Bethesda). 2012 Aug;27(4):213-22. doi: 10.1152/physiol.00016.2012.

An inside view: VEGF receptor trafficking and signaling.

Author information

1
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, Connecticut, USA. michael.simons@yale.edu

Abstract

Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function.

PMID:
22875452
PMCID:
PMC4037811
DOI:
10.1152/physiol.00016.2012
[Indexed for MEDLINE]
Free PMC Article

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