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Hematol Oncol Clin North Am. 2012 Aug;26(4):797-809. doi: 10.1016/j.hoc.2012.05.001. Epub 2012 Jun 7.

Low-grade gliomas: when and how to treat.

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Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.


Low-grade gliomas are uncommon tumors whose optimal management remains to be determined. Although well-designed clinical trials have been mounted to address certain aspects of postoperative radiotherapeutic management, additional studies are required to refine management based on tumor-specific and patient-specific variables. There is mounting evidence that the relative completeness of surgical resection can improve survival, and the molecular and histopathologic characterization of the glioma requires adequate samples for analysis. Current imaging and operative techniques can direct surgical resection, and the same imaging techniques can help monitor patients postoperatively and predict prognosis.

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