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J Neurosci. 2012 Jun 27;32(26):8988-99. doi: 10.1523/JNEUROSCI.0536-12.2012.

Global connectivity of prefrontal cortex predicts cognitive control and intelligence.

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1
Psychology Department, Washington University, St. Louis, Missouri 63130, USA. mwcole@mwcole.net

Abstract

Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism--global connectivity--by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence.

PMID:
22745498
PMCID:
PMC3392686
DOI:
10.1523/JNEUROSCI.0536-12.2012
[Indexed for MEDLINE]
Free PMC Article
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