[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene]

A V Beliaeva; G A Ianus; E N Suspithyn; O A Zaĭtseva; O S Iatsuk; A B Moiseenko; A V Guliaev; E N Imianitov

[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene]

Adv Gerontol. 2012;25(1):72-8.

[Article in Russian]

Authors

A V Beliaeva, G A Ianus, E N Suspithyn, O A Zaĭtseva, O S Iatsuk, A B Moiseenko, A V Guliaev, E N Imianitov

PMID: 22708448

Abstract

Activating mutation in K-ras gene is a key event in the pathogenesis of colon carcinoma. This study analyses frequency of this mutation in different age groups of colorectal cancer patients residing in North-Western Russia, and examines its relationship with essential clinical characteristics of tumor disease.

Publication types

English Abstract

MeSH terms

Adult
Aged
Aged, 80 and over
Aging / genetics*
Aging / pathology
Colonic Neoplasms / epidemiology
Colonic Neoplasms / genetics*
Colonic Neoplasms / pathology
Female
Genes, ras / genetics*
Humans
Male
Middle Aged
Mutation Rate
Mutation*
Polymerase Chain Reaction
Rectal Neoplasms / epidemiology
Rectal Neoplasms / genetics*
Rectal Neoplasms / pathology
Russia