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Cancer Cell. 2012 Jun 12;21(6):711-2. doi: 10.1016/j.ccr.2012.05.034.

CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction.

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Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.


Hepatocellular carcinoma is the outcome of ongoing cycles of cell death and regeneration in chronic liver disease. In this issue of Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling the balance between hepatocyte loss, regeneration, and malignant progression.

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