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Dev Cell. 2012 Apr 17;22(4):695-702. doi: 10.1016/j.devcel.2012.03.013.

Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling.

Author information

1
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.

Abstract

Over the past decade, the Hippo tumor suppressor pathway has emerged as a central regulator of growth in epithelial tissues. Research in Drosophila and in mammals has shown that this kinase signaling cascade regulates the activity of the transcriptional coactivator and oncoprotein Yorkie/Yap. In this review, we discuss recent findings that emphasize the cell cortex-specifically the actin cytoskeleton, intercellular junctions, and protein complexes that determine cell polarity-as a key site for Hippo pathway regulation. We also highlight where additional research is needed to integrate known functional interactions between Hippo pathway components.

PMID:
22516196
PMCID:
PMC3376383
DOI:
10.1016/j.devcel.2012.03.013
[Indexed for MEDLINE]
Free PMC Article

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