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AAPS PharmSciTech. 2012 Jun;13(2):513-21. doi: 10.1208/s12249-012-9768-5. Epub 2012 Mar 20.

Physicochemical performances of indomethacin in cholesteryl cetyl carbonate liquid crystal as a transdermal dosage.

Author information

1
Drug Delivery System Excellence Center, Prince of Songkla University, Hat Yai, Songkla, 90112, Thailand.

Abstract

A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5 % IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45 % within 24 h.

PMID:
22430922
PMCID:
PMC3364373
DOI:
10.1208/s12249-012-9768-5
[Indexed for MEDLINE]
Free PMC Article

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