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Laryngoscope. 2012 Apr;122(4):747-50. doi: 10.1002/lary.23212. Epub 2012 Feb 2.

Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment.

Author information

1
Department of Otolaryngology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei. chshu@vghtpe.gov.tw

Abstract

OBJECTIVES/HYPOTHESIS:

Oral corticosteroids may restore conductive olfactory dysfunction that has been defined as steroid-dependent olfactory loss, but the effect may be temporary. This study was designed to evaluate whether applying topical corticosteroids with a squirt system was more effective than using a nasal spray to maintain olfactory improvement following oral corticosteroids.

STUDY DESIGN:

Prospective randomized trial enrolling 32 patients.

METHODS:

Patients were enrolled if they had suffered from olfactory dysfunction for more than 3 months, and if their composite scores of odor threshold, discrimination, and identification scores in Sniffin' Sticks olfactory tests increased by more than six points after 1 week of oral corticosteroid treatment. A total of 32 patients were enrolled and randomized into two groups. All patients were treated with topical corticosteroids for 2 months using either the spray or squirt system, respectively.

RESULTS:

Both measured and self-rated olfactory functions after 1 and 2 months of topical corticosteroid treatment were better in the squirt group than in the spray group. However, 2 months of topical corticosteroid treatment with the squirt system only partially maintained olfactory improvement.

CONCLUSIONS:

The application of topical corticosteroids with a squirt system was more effective than with a spray in maintaining olfactory improvement with oral corticosteroid treatment. Nevertheless, it only partially maintained the improvement so that topical corticosteroid treatment using a squirt system needs to be combined with intervals of short-term oral corticosteroids to treat steroid-dependent olfactory loss while avoiding the side effects of long-term oral corticosteroid use.

PMID:
22302665
DOI:
10.1002/lary.23212
[Indexed for MEDLINE]

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