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Genesis. 2012 Mar;50(3):133-42. doi: 10.1002/dvg.22015. Epub 2012 Feb 20.

Xenopus white papers and resources: folding functional genomics and genetics into the frog.

Author information

1
Department of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. Mustafa.khokha@yale.edu

Abstract

The frog Xenopus has been vital for biomedical science for over 80 years, contributing to diverse fields from cell signaling, cell and developmental biology, to ion channel physiology and toxicology. Its experimentally manipulable oocytes and embryos provide abundant material for molecular and biochemical approaches for a wide range of gene discovery and protein function studies. In recent years, the Xenopus community has invested in key resources for functional genomics, including genome-wide full-length cDNA collections and genome assemblies as well as genetic tools. These assets combine with Xenopus' extensive range of functional assays to create exciting new research avenues with medical as well as basic applications. This review describes how these resources were developed and what new tools are on the horizon.

PMID:
22287484
DOI:
10.1002/dvg.22015
[Indexed for MEDLINE]
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