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J Am Chem Soc. 2012 Jan 25;134(3):1482-5. doi: 10.1021/ja211110h. Epub 2012 Jan 17.

Mechanism of the rhodium(III)-catalyzed arylation of imines via C-H bond functionalization: inhibition by substrate.

Author information

1
Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Abstract

Rh(III)-catalyzed arylation of imines provides a new method for C-C bond formation while simultaneously introducing an α-branched amine as a functional group. This detailed mechanistic study provides insights for the rational future development of this new reaction. Relevant intermediate Rh(III) complexes have been isolated and characterized, and their reactivities in stoichiometric reactions with relevant substrates have been monitored. The reaction was found to be first order in the catalyst resting state and inverse first order in the C-H activation substrate.

PMID:
22257031
PMCID:
PMC3269099
DOI:
10.1021/ja211110h
[Indexed for MEDLINE]
Free PMC Article

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