Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Mol Neurosci. 2011 Nov 18;4:43. doi: 10.3389/fnmol.2011.00043. eCollection 2011.

Visualization and manipulation of neural activity in the developing vertebrate nervous system.

Author information

1
Department of Neurobiology, Yale University New Haven, CT, USA.

Abstract

Neural activity during vertebrate development has been unambiguously shown to play a critical role in sculpting circuit formation and function. Patterned neural activity in various parts of the developing nervous system is thought to modulate neurite outgrowth, axon targeting, and synapse refinement. The nature and role of patterned neural activity during development has been classically studied with in vitro preparations using pharmacological manipulations. In this review we discuss newly available and developing molecular-genetic tools for the visualization and manipulation of neural activity patterns specifically during development.

KEYWORDS:

circuit; development; imaging; neuron; optogenetics; vision

PMID:
22121343
PMCID:
PMC3219918
DOI:
10.3389/fnmol.2011.00043
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center