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Arthritis Res Ther. 2011;13(5):240. doi: 10.1186/ar3378. Epub 2011 Sep 28.

Lupus nephritis: current update.

Author information

  • 1Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Ramesh.saxena@utsouthwestern.edu

Abstract

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how the disease is currently diagnosed and treated.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00657189 NCT00774852 NCT00962832.

PMID:
22078716
PMCID:
PMC3308062
DOI:
10.1186/ar3378
[PubMed - indexed for MEDLINE]
Free PMC Article
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