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Cells Tissues Organs. 2012;195(1-2):41-7. doi: 10.1159/000331423. Epub 2011 Oct 14.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine.

Author information

1
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Tex., USA.

Abstract

Although a 'vascular stem cell' population has not been identified or generated, vascular endothelial and mural cells (smooth muscle cells and pericytes) can be derived from currently known pluripotent stem cell sources including human embryonic stem cells and induced pluripotent stem cells. We review the vascular potential of these human pluripotent stem cells, the mechanisms by which they are induced to differentiate toward a vascular endothelial cell fate, and their applications in regenerative medicine.

PMID:
22005724
DOI:
10.1159/000331423
[Indexed for MEDLINE]

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