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Yale J Biol Med. 2011 Sep;84(3):301-9.

RNA-based gene therapy for the treatment and prevention of HIV: from bench to bedside.

Author information

1
Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06511, USA.

Abstract

Gene therapy is considered a feasible approach for the treatment and prevention of HIV/AIDS. Targeting both viral genes and host dependency factors can interfere with the viral lifecycle and prevent viral replication. A number of approaches have been taken to target these genes, including ribozymes, aptamers, and RNAi based therapies. A number of these therapies are now beginning to make their way into clinical trials and providing proof of principle that gene therapy is a safe and realistic option for treating HIV. Here, we focus on those therapies that have progressed along the pipeline to preclinical and clinical testing.

KEYWORDS:

Clinical Trial HIV; Gene therapy HIV; RNAi HIV; aptamer HIV; ribozyme HIV

PMID:
21966049
PMCID:
PMC3178861
[Indexed for MEDLINE]
Free PMC Article

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