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BMC Psychiatry. 2011 Sep 21;11:151. doi: 10.1186/1471-244X-11-151.

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

Author information

1
Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, México. alfonso_tovillaz@yahoo.com.mx

Abstract

BACKGROUND:

The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.

METHODS:

We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.

RESULTS:

No significant differences were found in the distribution of alleles (χ2 = 0.33, 1 df, p = 0.56) or genotypes (χ2 = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23).

CONCLUSION:

Our results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behavior.

PMID:
21936936
PMCID:
PMC3184265
DOI:
10.1186/1471-244X-11-151
[Indexed for MEDLINE]
Free PMC Article

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