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Cell. 2011 Sep 16;146(6):861-2. doi: 10.1016/j.cell.2011.08.027.

A new shield for a cytokine storm.

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Department of Immunobiology, School of Medicine, Yale University New Haven, CT 06520, USA.


Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network.

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