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J Biol Chem. 2011 Oct 28;286(43):37045-52. doi: 10.1074/jbc.R111.276964. Epub 2011 Sep 13.

Keeping the soma free of transposons: programmed DNA elimination in ciliates.

Author information

1
Institute of Molecular Biotechnology, Austrian Academy of Sciences (IMBA), A-1030 Vienna, Austria.

Abstract

Many transposon-related sequences are removed from the somatic macronucleus of ciliates during sexual reproduction. In the ciliate Tetrahymena, an RNAi-related mechanism produces small noncoding RNAs that induce heterochromatin formation, which is followed by DNA elimination. Because RNAi-related mechanisms repress transposon activities in a variety of eukaryotes, the DNA elimination mechanism of ciliates might have evolved from these types of transposon-silencing mechanisms. Nuclear dimorphism allows ciliates to identify any DNA that has invaded the germ-line micronucleus using small RNAs and a whole genome comparison of the micronucleus and the somatic macronucleus.

PMID:
21914793
PMCID:
PMC3199450
DOI:
10.1074/jbc.R111.276964
[Indexed for MEDLINE]
Free PMC Article

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