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Cancer Res. 2011 Aug 15;71(16):5370-3. doi: 10.1158/0008-5472.CAN-11-1044. Epub 2011 Aug 9.

B-Myb, cancer, senescence, and microRNAs.

Author information

1
Department of Genetics and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, Connecticut 06520-8005, USA.

Abstract

The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the abundance of B-Myb mRNA during senescence, adding another level of complexity to B-Myb regulation. This review focuses on the importance of B-Myb in cancer and senescence, with an emphasis on the regulation of B-Myb expression and activity.

PMID:
21828240
PMCID:
PMC3156249
DOI:
10.1158/0008-5472.CAN-11-1044
[Indexed for MEDLINE]
Free PMC Article

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