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Biosens Bioelectron. 2011 Oct 15;28(1):239-42. doi: 10.1016/j.bios.2011.07.025. Epub 2011 Jul 23.

Multiplexed SOI BioFETs.

Author information

1
Department of Electrical, Yale University, 15 Prospect St., New Haven, CT 06511, USA. aleksandar.vacic@yale.edu

Abstract

Nanoscale Field Effect Transistors have emerged as a promising technology for ultrasensitive, unlabeled diagnostic applications. However, their use as quantitative sensors has been problematic because of the need for individual sensor calibration. In this work we demonstrate an internal calibration scheme for multiplexed nanoribbon field effect sensors by utilizing the initial current rates rather than end point detection. A linear response is observed consistent with initial binding kinetics. Moreover, we are able to show that top-down fabrication techniques yield reproducible device results with minimal fluctuations, enabling internal calibration.

PMID:
21820303
PMCID:
PMC3235496
DOI:
10.1016/j.bios.2011.07.025
[Indexed for MEDLINE]
Free PMC Article

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