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J Am Chem Soc. 2011 Sep 7;133(35):13886-9. doi: 10.1021/ja205684a. Epub 2011 Aug 16.

Determination of molecular configuration by debye length modulation.

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Departments of Electrical, Yale University, New Haven, Connecticut 06511, United States.


Silicon nanowire field effect transistors (FETs) have emerged as ultrasensitive, label-free biodetectors that operate by sensing bound surface charge. However, the ionic strength of the environment (i.e., the Debye length of the solution) dictates the effective magnitude of the surface charge. Here, we show that control of the Debye length determines the spatial extent of sensed bound surface charge on the sensor. We apply this technique to different methods of antibody immobilization, demonstrating different effective distances of induced charge from the sensor surface.

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