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Mol Cell Neurosci. 2011 Oct;48(2):142-50. doi: 10.1016/j.mcn.2011.07.003. Epub 2011 Jul 21.

IL-1β inhibits axonal growth of developing sympathetic neurons.

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Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland.


Several secreted proteins facilitate the growth and guidance of sympathetic axons to their target organs during development. Here we show that IL-1β, a key regulator of inflammation in the immune system, inhibits axonal growth and branching from cultured sympathetic neurons at a stage in development when their axons are ramifying within their targets in vivo. IL-1β is synthesised in sympathetic ganglia and its targets at this stage, and IL-1β protein is detectable in the axons and perikarya of the innervating neurons. It acts directly on developing axons to inhibit their growth via NF-κB signalling. These findings show that IL-1β is a novel locally, and target-derived factor that can regulate the extent of sympathetic axon growth during the late embryonic and early postnatal period in developing rat sympathetic neurons.

[Indexed for MEDLINE]

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