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Immunity. 2011 Jul 22;35(1):3-5. doi: 10.1016/j.immuni.2011.07.006.

Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction.

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Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.


Unc93B1, a multitransmembrane ER-resident protein, controls intracellular trafficking of endosomal Toll-like receptors. In this issue of Immunity, Fukui et al. (2011) revealed that Unc93B1 regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity.

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