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PLoS One. 2011;6(7):e21952. doi: 10.1371/journal.pone.0021952. Epub 2011 Jul 7.

Water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPARγ and C/EBPα expression.

Author information

1
Iwate Biotechnology Research Center, Kitakami, Iwate, Japan. hyamada@ibrc.or.jp

Abstract

BACKGROUND:

Pacific Krill (Euphausia pacifica) are small, red crustaceans, similar to shrimp, that flourish in the North Pacific and are eaten in Japan.

METHODS AND FINDINGS:

We investigated the effect of a water-soluble extract of Pacific Krill on adipocytes and discovered that this extract suppressed triglyceride accumulation in adipocytes. Furthermore, the water-soluble extract of Pacific Krill suppressed the expression of two master regulators of adipocyte differentiation, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα). C/EBPβ promotes PPARγ and C/EBPα expression, but the water-soluble extract of Pacific Krill did not inhibit the expression of C/EBPβ or C/EBPβ-mediated transcriptional activation. The Pacific Krill extract was more effective than a PPARγ antagonist in suppressing PPARγ and C/EBPα expression.

CONCLUSIONS:

These results indicated that the water-soluble extract of Pacific Krill was not simply a PPARγ antagonist, but that it prevented triglyceride accumulation in adipocytes by suppression of PPARγ and C/EBPα via a pathway that is independent of C/EBPβ.

PMID:
21760932
PMCID:
PMC3131400
DOI:
10.1371/journal.pone.0021952
[Indexed for MEDLINE]
Free PMC Article

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