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J Am Chem Soc. 2011 Aug 3;133(30):11430-3. doi: 10.1021/ja203495c. Epub 2011 Jul 8.

Expedient synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates.

Author information

1
Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Abstract

A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C-H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.

PMID:
21714533
PMCID:
PMC3158987
DOI:
10.1021/ja203495c
[Indexed for MEDLINE]
Free PMC Article

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