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Nat Rev Mol Cell Biol. 2011 Jun;12(6):392-8. doi: 10.1038/nrm3120.

Turing's next steps: the mechanochemical basis of morphogenesis.

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1
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. howard@mpi-cbg.de

Abstract

Nearly 60 years ago, Alan Turing showed theoretically how two chemical species, termed morphogens, diffusing and reacting with each other can generate spatial patterns. Diffusion plays a crucial part in transporting chemical signals through space to establish the length scale of the pattern. When coupled to chemical reactions, mechanical processes - forces and flows generated by motor proteins - can also define length scales and provide a mechanochemical basis for morphogenesis. forces and flows generated by motor proteins - can also define length scales and provide a mechanochemical basis for morphogenesis.

PMID:
21602907
DOI:
10.1038/nrm3120
[Indexed for MEDLINE]
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