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Mol Cell. 2011 May 20;42(4):411-2. doi: 10.1016/j.molcel.2011.05.001.

"Competence" progress.

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Department of Pathology and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.


Zwang et al. (2011) have identified outputs of two EGF pulses that commit cells to cycle. The first induces components for lipid biosynthesis and sets up an inhibitory latch through p53. The second works through ERK to EGR1 and releases the latch to promote restriction point traverse.

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