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Nat Cell Biol. 2011 Jun;13(6):686-92. doi: 10.1038/ncb2232. Epub 2011 May 15.

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.

Author information

1
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

Angiogenesis, the formation of new blood vessels from pre-existing vessels, is critical to most physiological processes and many pathological conditions. During zebrafish development, angiogenesis expands the axial vessels into a complex vascular network that is necessary for efficient oxygen delivery. Although the dorsal aorta and the axial vein are spatially juxtaposed, the initial angiogenic sprouts from these vessels extend in opposite directions, indicating that distinct cues may regulate angiogenesis of the axial vessels. We found that angiogenic sprouts from the dorsal aorta are dependent on vascular endothelial growth factor A (Vegf-A) signalling, and do not respond to bone morphogenetic protein (Bmp) signals. In contrast, sprouts from the axial vein are regulated by Bmp signalling independently of Vegf-A signals, indicating that Bmp is a vein-specific angiogenic cue during early vascular development. Our results support a paradigm whereby different signals regulate distinct programmes of sprouting angiogenesis from the axial vein and dorsal aorta, and indicate that signalling heterogeneity contributes to the complexity of vascular networks.

PMID:
21572418
PMCID:
PMC3107371
DOI:
10.1038/ncb2232
[Indexed for MEDLINE]
Free PMC Article

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